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CMap Candidate Details

Structure:
CMap ID: C04755
Pert ID: BRD-K92613113
Compound Name: safinamide
Targets: MAOB
MoA: dopamine uptake inhibitor; glutamate inhibitor; monoamine oxidase inhibitor
SMILES: C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128369 BRD-K92613113 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128406 BRD-K92613113 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
128417 BRD-K92613113 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128470 BRD-K92613113 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
128527 BRD-K92613113 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128583 BRD-K92613113 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128620 BRD-K92613113 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128700 BRD-K92613113 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.52
128752 BRD-K92613113 YAPC 0.37 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
136162 BRD-K92613113 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136283 BRD-K92613113 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136328 BRD-K92613113 MCF??7.00 0.01 uM 24 h -0.17 -0.71 0.0 -0.25 -0.85 0.19
136357 BRD-K92613113 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).