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CMap Candidate Details

Structure:
CMap ID: C00478
Pert ID: BRD-K16295392
Compound Name: atrasentan
Targets: EDNRA
MoA: endothelin receptor antagonist
SMILES: CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90591 BRD-K16295392 HCT116 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90655 BRD-K16295392 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98047 BRD-K16295392 P1A82 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120235 BRD-K16295392 A375 10 uM 24 h -0.29 -1.2 0.57 0.0 0.0 0.0
120270 BRD-K16295392 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.02
120307 BRD-K16295392 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120399 BRD-K16295392 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
120430 BRD-K16295392 PC3 0.04 uM 24 h 0.24 0.98 0.09 0.33 1.17 0.92
120464 BRD-K16295392 YAPC 0.37 uM 24 h -0.23 -0.94 0.08 0.23 0.8 0.08
128922 BRD-K16295392 HELA 0.03 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
128941 BRD-K16295392 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).