CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04797
Pert ID:	BRD-K54330070
Compound Name:	SB-202190
Targets:	AKT1\|ALOX5\|CHEK1\|GSK3B\|LCK\|MAPK1\|MAPK11\|MAPK12\|MAPK14\|MAPK8\|PRKCA\|ROCK1\|RPS6KB1\|SGK1
MoA:	p38 MAPK inhibitor
SMILES:	Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3040	BRD-K54330070	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
3525	BRD-K54330070	PC3	10 uM	24 h	0.22	0.91	0.03	-0.2	-0.69	0.02
3832	BRD-K54330070	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39145	BRD-K54330070	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39715	BRD-K54330070	ASC	10 uM	24 h	-0.27	-1.12	0.38	0.0	0.0	0.0
41471	BRD-K54330070	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99056	BRD-K54330070	NEU	10 uM	6 h	-0.22	-0.9	0.04	0.0	0.0	0.0
99239	BRD-K54330070	NPC	10 uM	6 h	0.0	0.0	0.0	0.34	1.19	1.03
99655	BRD-K54330070	U2OS	15 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
115995	BRD-K54330070	A549	1.11 uM	24 h	0.0	0.0	0.0	-0.4	-1.33	1.84
116078	BRD-K54330070	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116120	BRD-K54330070	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116167	BRD-K54330070	HT29	10 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
116207	BRD-K54330070	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary