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CMap Candidate Details

Structure:
CMap ID: C04803
Pert ID: BRD-K59184148
Compound Name: SB-216763
Targets: CCNA2|CDK2|GSK3A|GSK3B
MoA: glycogen synthase kinase inhibitor
SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2ccc(Cl)cc2Cl)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8960 BRD-K59184148 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9108 BRD-K59184148 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9458 BRD-K59184148 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9764 BRD-K59184148 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9879 BRD-K59184148 HA1E 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
10255 BRD-K59184148 HCC515 10 uM 6 h 0.0 0.0 0.0 0.22 0.77 0.06
10547 BRD-K59184148 HCT116 10 uM 6 h 0.0 0.0 0.0 0.38 1.34 1.72
11058 BRD-K59184148 HT29 10 uM 6 h 0.18 0.74 0.0 -0.38 -1.29 1.53
11137 BRD-K59184148 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11522 BRD-K59184148 NCIH2073 10 uM 6 h -0.14 -0.58 0.0 0.0 0.0 0.0
11793 BRD-K59184148 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12085 BRD-K59184148 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
12343 BRD-K59184148 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12437 BRD-K59184148 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12822 BRD-K59184148 SW480 10 uM 6 h 0.31 1.31 0.76 0.3 1.07 0.64
12938 BRD-K59184148 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13310 BRD-K59184148 U937 10 uM 6 h 0.29 1.19 0.42 0.3 1.04 0.56
90324 BRD-K59184148 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91818 BRD-K59184148 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91845 BRD-K59184148 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91968 BRD-K59184148 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92918 BRD-K59184148 ASC 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
92976 BRD-K59184148 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93068 BRD-K59184148 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93115 BRD-K59184148 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93154 BRD-K59184148 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
93203 BRD-K59184148 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93259 BRD-K59184148 JURKAT 10 uM 24 h -0.24 -0.98 0.12 0.26 0.92 0.25
93345 BRD-K59184148 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93411 BRD-K59184148 NPC 10 uM 24 h 0.23 0.97 0.08 -0.31 -1.04 0.67
93472 BRD-K59184148 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93571 BRD-K59184148 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98914 BRD-K59184148 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99701 BRD-K59184148 U2OS 10 uM 6 h 0.0 0.0 0.0 0.23 0.83 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).