CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04817
Pert ID:	BRD-K82467063
Compound Name:	SB-271046
Targets:	HTR6
MoA:	serotonin receptor antagonist
SMILES:	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125963	BRD-K82467063	A375	10 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.13
125982	BRD-K82467063	A549	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
126003	BRD-K82467063	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126050	BRD-K82467063	HT29	10 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.51
126080	BRD-K82467063	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.21
126125	BRD-K82467063	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126178	BRD-K82467063	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126218	BRD-K82467063	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.62
126237	BRD-K82467063	MDAMB231	10 uM	24 h	0.19	0.79	0.0	0.37	1.3	1.58
126297	BRD-K82467063	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126339	BRD-K82467063	YAPC	10 uM	24 h	-0.13	-0.56	0.0	0.24	0.84	0.13
134099	BRD-K82467063	HEK293	0.01 uM	24 h	-0.22	-0.93	0.07	-0.38	-1.26	1.38
134146	BRD-K82467063	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.3	1.08	0.65
134286	BRD-K82467063	PC3	0.01 uM	24 h	0.25	1.06	0.19	0.0	0.0	0.0

Summary