CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04823
Pert ID:	BRD-K53913732
Compound Name:	SB-408124
Targets:	HCRTR1\|HCRTR2
MoA:	orexin receptor antagonist
SMILES:	CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2901	BRD-K53913732	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.66
3230	BRD-K53913732	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.67
39459	BRD-K53913732	A549	10 uM	6 h	-0.25	-1.05	0.24	-0.24	-0.81	0.14
39712	BRD-K53913732	ASC	10 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
40016	BRD-K53913732	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40288	BRD-K53913732	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40479	BRD-K53913732	MCF??7.00	10 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
40826	BRD-K53913732	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41133	BRD-K53913732	NPC	10 uM	24 h	0.0	0.0	0.0	0.37	1.29	1.49
41468	BRD-K53913732	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90370	BRD-K53913732	PC3	3.33 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.36
90411	BRD-K53913732	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96621	BRD-K53913732	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary