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CMap Candidate Details

Structure:
CMap ID: C04824
Pert ID: BRD-K76805682
Compound Name: SB-415286
Targets: GSK3A|GSK3B|RPS6KB1
MoA: glycogen synthase kinase inhibitor
SMILES: Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4252 BRD-K76805682 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4595 BRD-K76805682 HCC515 10 uM 6 h 0.28 1.15 0.33 -0.19 -0.63 0.01
4719 BRD-K76805682 PC3 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
5124 BRD-K76805682 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37188 BRD-K76805682 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37411 BRD-K76805682 A549 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
37737 BRD-K76805682 ASC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
37945 BRD-K76805682 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.75
38107 BRD-K76805682 HT29 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.72
38222 BRD-K76805682 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38553 BRD-K76805682 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39004 BRD-K76805682 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90825 BRD-K76805682 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99485 BRD-K76805682 U2OS 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.98
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).