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CMap Candidate Details

Structure:
CMap ID: C04828
Pert ID: BRD-K37720887
Compound Name: SB-525334
Targets: TGFBR1
MoA: TGF beta receptor inhibitor
SMILES: Cc1cccc(n1)-c1[nH]c(nc1-c1ccc2nccnc2c1)C(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
36553 BRD-K37720887 SKB 10 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
36817 BRD-K37720887 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91801 BRD-K37720887 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91933 BRD-K37720887 SKBR3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92941 BRD-K37720887 ASC 0.12 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
93008 BRD-K37720887 CD34 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
93048 BRD-K37720887 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93095 BRD-K37720887 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
93136 BRD-K37720887 HELA 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
93234 BRD-K37720887 HUVEC 0.37 uM 24 h 0.32 1.34 0.89 0.0 0.0 0.0
93287 BRD-K37720887 JURKAT 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
93323 BRD-K37720887 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.03 0.62
93367 BRD-K37720887 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
93401 BRD-K37720887 NPC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
93454 BRD-K37720887 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93493 BRD-K37720887 SKL 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
93552 BRD-K37720887 THP1 0.12 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.62
93592 BRD-K37720887 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96059 BRD-K37720887 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96139 BRD-K37720887 A549 10 uM 24 h 0.23 0.95 0.07 -0.26 -0.88 0.25
117010 BRD-K37720887 A375 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.49 15.35
117126 BRD-K37720887 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
117174 BRD-K37720887 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
117221 BRD-K37720887 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117260 BRD-K37720887 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).