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CMap Candidate Details

Structure:
CMap ID: C00483
Pert ID: BRD-K12040459
Compound Name: AT7867
Targets: AKT2|GSK3B|PKIA|PRKACA
MoA: AKT inhibitor
SMILES: Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91795 BRD-K12040459 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.26 0.92 0.25
91874 BRD-K12040459 MCF??7.00 2.22 uM 6 h 0.0 0.0 0.0 0.33 1.18 1.01
91957 BRD-K12040459 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92882 BRD-K12040459 A375 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
92910 BRD-K12040459 A549 10 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
92966 BRD-K12040459 ASC 10 uM 24 h -0.16 -0.67 0.0 0.29 1.03 0.52
93023 BRD-K12040459 CD34 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
93057 BRD-K12040459 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93108 BRD-K12040459 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93147 BRD-K12040459 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93191 BRD-K12040459 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93249 BRD-K12040459 HUVEC 10 uM 24 h -0.19 -0.81 0.0 0.0 0.0 0.0
93299 BRD-K12040459 JURKAT 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
93335 BRD-K12040459 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
93377 BRD-K12040459 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93433 BRD-K12040459 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93464 BRD-K12040459 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93522 BRD-K12040459 SKL 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.68
93563 BRD-K12040459 THP1 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
93603 BRD-K12040459 YAPC 10 uM 24 h -0.22 -0.9 0.04 0.38 1.35 1.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).