CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04838
Pert ID:	BRD-K45168550
Compound Name:	SB-756050
Targets:	GPBAR1
MoA:	G protein-coupled receptor agonist
SMILES:	COc1ccc(cc1OC)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)c1ccc(OC)c(OC)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125273	BRD-K45168550	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.24
125297	BRD-K45168550	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125349	BRD-K45168550	HELA	10 uM	24 h	-0.26	-1.07	0.27	0.32	1.13	0.81
125392	BRD-K45168550	JURKAT	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
125414	BRD-K45168550	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125433	BRD-K45168550	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125486	BRD-K45168550	PC3	10 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
125543	BRD-K45168550	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133331	BRD-K45168550	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133356	BRD-K45168550	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133444	BRD-K45168550	HT29	2.22 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.09
133542	BRD-K45168550	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133597	BRD-K45168550	THP1	0.25 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0

Summary