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CMap Candidate Details

Structure:
CMap ID: C04873
Pert ID: BRD-K65820248
Compound Name: SDZ-NKT-343
Targets: TACR1
MoA: tachykinin antagonist
SMILES: CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+]([O-])=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124974 BRD-K65820248 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125036 BRD-K65820248 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125057 BRD-K65820248 HT29 10 uM 24 h -0.28 -1.16 0.45 0.25 0.87 0.17
125079 BRD-K65820248 MCF10A 0.125 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
125136 BRD-K65820248 PC3 10 uM 24 h -0.23 -0.95 0.09 -0.35 -1.16 1.11
125176 BRD-K65820248 THP1 0.37 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
125217 BRD-K65820248 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132984 BRD-K65820248 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133017 BRD-K65820248 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133064 BRD-K65820248 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133171 BRD-K65820248 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
133234 BRD-K65820248 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133267 BRD-K65820248 MDAMB231 0.01 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).