CMap Candidate Details
Structure:
| CMap ID: | C00488 |
| Pert ID: | BRD-K23190681 |
| Compound Name: | AV-412 |
| Targets: | EGFR|ERBB2 |
| MoA: | protein tyrosine kinase inhibitor |
| SMILES: | CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 121425 | BRD-K23190681 | HELA | 3.33 uM | 24 h | 0.22 | 0.92 | 0.04 | 0.0 | 0.0 | 0.0 |
| 121449 | BRD-K23190681 | HT29 | 10 uM | 24 h | -0.2 | -0.84 | 0.01 | 0.0 | 0.0 | 0.0 |
| 121469 | BRD-K23190681 | MCF??7.00 | 3.33 uM | 24 h | -0.2 | -0.82 | 0.0 | -0.27 | -0.9 | 0.29 |
| 121539 | BRD-K23190681 | YAPC | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129416 | BRD-K23190681 | A375 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129453 | BRD-K23190681 | HA1E | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129566 | BRD-K23190681 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.93 | 0.36 |