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CMap Candidate Details

Structure:
CMap ID: C04894
Pert ID: BRD-K81957469
Compound Name: semagacestat
Targets: PSEN1
MoA: gamma secretase inhibitor
SMILES: CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@@H]1c2ccccc2CCN(C)C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126368 BRD-K81957469 A375 10 uM 24 h -0.2 -0.83 0.0 0.28 1.0 0.43
126389 BRD-K81957469 A549 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
126456 BRD-K81957469 HEK293 1.11 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
126501 BRD-K81957469 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134411 BRD-K81957469 HA1E 2.22 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
134440 BRD-K81957469 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134523 BRD-K81957469 HUVEC 0.74 uM 24 h -0.37 -1.54 1.43 -0.38 -1.26 1.39
134549 BRD-K81957469 MCF10A 0.74 uM 24 h -0.23 -0.98 0.12 0.27 0.95 0.32
134577 BRD-K81957469 MCF??7.00 2.22 uM 24 h 0.39 1.61 1.55 -0.19 -0.65 0.01
134610 BRD-K81957469 MDAMB231 2.22 uM 24 h -0.25 -1.06 0.25 -0.31 -1.03 0.62
134635 BRD-K81957469 PC3 0.25 uM 24 h 0.29 1.23 0.49 0.0 0.0 0.0
134659 BRD-K81957469 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).