CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04896
Pert ID:	BRD-K63504947
Compound Name:	semaxanib
Targets:	FGFR1\|FLT1\|KDR\|KIT\|PDGFRA\|PDGFRB\|RET
MoA:	VEGFR inhibitor
SMILES:	Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4456	BRD-K63504947	HCC515	10 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.38
4946	BRD-K63504947	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.81
39730	BRD-K63504947	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40027	BRD-K63504947	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.99	0.5
40841	BRD-K63504947	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41148	BRD-K63504947	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41486	BRD-K63504947	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95610	BRD-K63504947	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	-0.44	-1.47	15.35
95639	BRD-K63504947	U2OS	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124964	BRD-K63504947	A549	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125024	BRD-K63504947	HELA	10 uM	24 h	-0.17	-0.72	0.0	0.0	0.0	0.0
125075	BRD-K63504947	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125161	BRD-K63504947	THP1	10 uM	24 h	-0.27	-1.1	0.36	0.0	0.0	0.0
132978	BRD-K63504947	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133013	BRD-K63504947	HA1E	0.25 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
133047	BRD-K63504947	HEK293	0.08 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.22
133115	BRD-K63504947	HT29	2.22 uM	24 h	0.29	1.2	0.43	0.0	0.0	0.0
133154	BRD-K63504947	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133259	BRD-K63504947	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35
133290	BRD-K63504947	PC3	2.22 uM	24 h	0.23	0.96	0.07	0.0	0.0	0.0
133314	BRD-K63504947	YAPC	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary