CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00049
Pert ID:	BRD-K64034691
Compound Name:	acalabrutinib
Targets:	BTK
MoA:	Bruton's tyrosine kinase (BTK) inhibitor
SMILES:	CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
87332	BRD-K64034691	BJAB	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
87376	BRD-K64034691	HBL1	10 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.24
87425	BRD-K64034691	K562	0.125 uM	24 h	0.0	0.0	0.0	-0.27	-0.89	0.27
87473	BRD-K64034691	KMS34	0.01 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
87490	BRD-K64034691	MINO	2.5 uM	24 h	0.0	0.0	0.0	0.22	0.8	0.08
87577	BRD-K64034691	NALM6	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87628	BRD-K64034691	OCILY10	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87677	BRD-K64034691	OCILY19	0.01 uM	24 h	-0.18	-0.73	0.0	0.32	1.14	0.85
87729	BRD-K64034691	OCILY3	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87776	BRD-K64034691	SKMEL5	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87796	BRD-K64034691	THP1	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87839	BRD-K64034691	TMD8	0.01 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.82
95533	BRD-K64034691	A549	10 uM	6 h	0.0	0.0	0.0	0.23	0.82	0.1
95578	BRD-K64034691	MCF??7.00	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
95618	BRD-K64034691	U2OS	1.11 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0

Summary