CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04908
Pert ID:	BRD-K69116396
Compound Name:	sertindole
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|DRD2\|DRD3\|DRD4\|HRH1\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2A\|HTR2C\|HTR6\|KCNH2
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126626	BRD-K69116396	A375	10 uM	24 h	0.27	1.13	0.29	0.38	1.34	1.72
126648	BRD-K69116396	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126670	BRD-K69116396	HA1E	10 uM	24 h	0.26	1.1	0.24	0.0	0.0	0.0
126688	BRD-K69116396	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.2
126711	BRD-K69116396	HELA	10 uM	24 h	0.0	0.0	0.0	0.22	0.79	0.08
126738	BRD-K69116396	HT29	10 uM	24 h	-0.16	-0.66	0.0	0.24	0.86	0.16
126767	BRD-K69116396	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126799	BRD-K69116396	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126834	BRD-K69116396	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.42	-1.42	2.53
126877	BRD-K69116396	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.38	1.36	1.72
126939	BRD-K69116396	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126986	BRD-K69116396	YAPC	10 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0
134854	BRD-K69116396	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134959	BRD-K69116396	PC3	2.22 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0

Summary