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CMap Candidate Details

Structure:
CMap ID: C00491
Pert ID: BRD-K65781196
Compound Name: avanafil
Targets: PDE5A
MoA: phosphodiesterase inhibitor
SMILES: COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95690 BRD-K65781196 U2OS 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97028 BRD-K65781196 A375 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
124977 BRD-K65781196 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
125006 BRD-K65781196 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125037 BRD-K65781196 HELA 3.33 uM 24 h -0.26 -1.08 0.29 -0.21 -0.69 0.02
125058 BRD-K65781196 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.24
125080 BRD-K65781196 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125119 BRD-K65781196 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.55
125138 BRD-K65781196 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125179 BRD-K65781196 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
125219 BRD-K65781196 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133067 BRD-K65781196 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133174 BRD-K65781196 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133237 BRD-K65781196 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).