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CMap Candidate Details

Structure:
CMap ID: C00492
Pert ID: BRD-K67901620
Compound Name: avasimibe
Targets: CES1
MoA: ACAT inhibitor
SMILES: CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126643 BRD-K67901620 A549 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
126662 BRD-K67901620 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126684 BRD-K67901620 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.49
126732 BRD-K67901620 HT29 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
126792 BRD-K67901620 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126823 BRD-K67901620 MCF??7.00 10 uM 24 h 0.18 0.77 0.0 -0.35 -1.17 1.12
126865 BRD-K67901620 MDAMB231 0.37 uM 24 h 0.25 1.02 0.13 0.0 0.0 0.0
126907 BRD-K67901620 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126926 BRD-K67901620 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134666 BRD-K67901620 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
134784 BRD-K67901620 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134841 BRD-K67901620 HUVEC 2.22 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
134893 BRD-K67901620 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134981 BRD-K67901620 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).