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CMap Candidate Details

Structure:
CMap ID: C04922
Pert ID: BRD-K19477839
Compound Name: SGX523
Targets: MET
MoA: hepatocyte growth factor receptor inhibitor
SMILES: Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91797 BRD-K19477839 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91911 BRD-K19477839 MDAMB231 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
91930 BRD-K19477839 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.05
94459 BRD-K19477839 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94519 BRD-K19477839 ASC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94567 BRD-K19477839 CD34 0.12 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
94611 BRD-K19477839 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94655 BRD-K19477839 HEK293 0.12 uM 24 h -0.31 -1.27 0.74 -0.24 -0.8 0.12
94762 BRD-K19477839 HME1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94854 BRD-K19477839 HUVEC 0.37 uM 24 h 0.26 1.09 0.22 0.19 0.67 0.01
94904 BRD-K19477839 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94950 BRD-K19477839 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95032 BRD-K19477839 NEU 1.11 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
95059 BRD-K19477839 NPC 10 uM 24 h 0.22 0.94 0.05 0.28 0.99 0.39
95129 BRD-K19477839 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95180 BRD-K19477839 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
95219 BRD-K19477839 SKL 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95289 BRD-K19477839 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
121402 BRD-K19477839 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121503 BRD-K19477839 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129400 BRD-K19477839 A375 0.03 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
129430 BRD-K19477839 HA1E 0.03 uM 24 h -0.22 -0.94 0.07 0.27 0.96 0.34
129485 BRD-K19477839 HT29 0.01 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
129515 BRD-K19477839 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).