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CMap Candidate Details

Structure:
CMap ID: C04929
Pert ID: BRD-A23359898
Compound Name: sibutramine
Targets: SLC6A2|SLC6A3|SLC6A4
MoA: serotonin norepinephrine reuptake inhibitor (SNRI)
SMILES: CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24373 BRD-A23359898 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24518 BRD-A23359898 A549 10 uM 24 h 0.24 1.0 0.11 -0.26 -0.88 0.26
24712 BRD-A23359898 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24834 BRD-A23359898 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24983 BRD-A23359898 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25212 BRD-A23359898 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25280 BRD-A23359898 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91455 BRD-A23359898 HUH7 12 uM 72 h 0.0 0.0 0.0 -0.39 -1.33 1.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).