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CMap Candidate Details

Structure:
CMap ID: C04932
Pert ID: BRD-K79759585
Compound Name: sildenafil
Targets: PDE5A|PDE6G|PDE6H|SLCO1B1|SLCO1B3
MoA: phosphodiesterase inhibitor
SMILES: CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5479 BRD-K79759585 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6322 BRD-K79759585 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37743 BRD-K79759585 ASC 10 uM 24 h -0.19 -0.78 0.0 -0.29 -0.97 0.44
38559 BRD-K79759585 NPC 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
39008 BRD-K79759585 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91129 BRD-K79759585 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
97623 BRD-K79759585 NKDBA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116273 BRD-K79759585 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116321 BRD-K79759585 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
116404 BRD-K79759585 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116453 BRD-K79759585 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116506 BRD-K79759585 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116554 BRD-K79759585 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127193 BRD-K79759585 MCF10A 0.125 uM 24 h -0.24 -0.99 0.13 -0.31 -1.05 0.7
127260 BRD-K79759585 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.42
127299 BRD-K79759585 THP1 0.04 uM 24 h -0.17 -0.71 0.0 -0.2 -0.69 0.02
135122 BRD-K79759585 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135135 BRD-K79759585 HELA 0.01 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
135192 BRD-K79759585 JURKAT 0.01 uM 24 h -0.17 -0.7 0.0 0.0 0.0 0.0
135292 BRD-K79759585 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135337 BRD-K79759585 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).