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CMap Candidate Details

Structure:
CMap ID: C00496
Pert ID: BRD-K87782578
Compound Name: AVL-292
Targets: BTK|YES1
MoA: Bruton's tyrosine kinase (BTK) inhibitor
SMILES: COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
76 BRD-K87782578 HBL1 0.04 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
141 BRD-K87782578 K562 10 uM 4 h -0.3 -1.24 0.64 0.0 0.0 0.0
159 BRD-K87782578 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
202 BRD-K87782578 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
279 BRD-K87782578 OCILY19 0.01 uM 24 h 0.28 1.17 0.38 0.0 0.0 0.0
358 BRD-K87782578 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
397 BRD-K87782578 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
433 BRD-K87782578 TMD8 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87313 BRD-K87782578 BJAB 10 uM 6 h 0.25 1.06 0.18 -0.34 -1.16 1.1
87512 BRD-K87782578 MINO 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87591 BRD-K87782578 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87691 BRD-K87782578 OCILY3 10 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
95512 BRD-K87782578 A549 10 uM 48 h 0.0 0.0 0.0 0.25 0.88 0.19
95604 BRD-K87782578 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95709 BRD-K87782578 U2OS 10 uM 6 h 0.28 1.15 0.32 0.0 0.0 0.0
127722 BRD-K87782578 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127807 BRD-K87782578 HA1E 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.53
127838 BRD-K87782578 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127912 BRD-K87782578 HUVEC 1.11 uM 24 h -0.22 -0.92 0.06 -0.33 -1.11 0.9
127968 BRD-K87782578 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128035 BRD-K87782578 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128062 BRD-K87782578 YAPC 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
135539 BRD-K87782578 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135594 BRD-K87782578 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135631 BRD-K87782578 JURKAT 2.22 uM 24 h 0.26 1.08 0.22 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).