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CMap Candidate Details

Structure:
CMap ID: C04977
Pert ID: BRD-K89561498
Compound Name: SN-38
Targets: TOP1
MoA: topoisomerase inhibitor
SMILES: CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(O)cc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121728 BRD-K89561498 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121749 BRD-K89561498 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121828 BRD-K89561498 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121880 BRD-K89561498 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129856 BRD-K89561498 HEK293 0.25 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
129884 BRD-K89561498 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
129905 BRD-K89561498 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129981 BRD-K89561498 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130067 BRD-K89561498 MDAMB231 0.74 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
130091 BRD-K89561498 PC3 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
130138 BRD-K89561498 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).