CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05016
Pert ID:	BRD-K23984367
Compound Name:	sorafenib
Targets:	BRAF\|DDR2\|FGFR1\|FLT1\|FLT3\|FLT4\|KDR\|KIT\|PDGFRB\|RAF1\|RET
MoA:	FLT3 inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; RAF inhibitor; RET tyrosine kinase inhibitor; VEGFR inhibitor
SMILES:	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1240	BRD-K23984367	A549	10 uM	48 h	0.0	0.0	0.0	-0.28	-0.94	0.36
1318	BRD-K23984367	U2OS	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
30396	BRD-K23984367	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
30996	BRD-K23984367	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.95	0.4
31301	BRD-K23984367	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
32383	BRD-K23984367	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32980	BRD-K23984367	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
33261	BRD-K23984367	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90800	BRD-K23984367	HPTEC	3.33 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
92450	BRD-K23984367	BT20	0.12 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
92488	BRD-K23984367	HA1E	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92521	BRD-K23984367	HME1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92573	BRD-K23984367	HS578T	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92618	BRD-K23984367	HT29	10 uM	24 h	0.25	1.05	0.16	0.0	0.0	0.0
92650	BRD-K23984367	LNCAP	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
92720	BRD-K23984367	MCF10A	10 uM	3 h	-0.28	-1.17	0.49	0.0	0.0	0.0
92784	BRD-K23984367	MDAMB231	10 uM	3 h	0.0	0.0	0.0	0.42	1.47	2.24
92796	BRD-K23984367	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92823	BRD-K23984367	SKBR3	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.4
98875	BRD-K23984367	NEU	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
121428	BRD-K23984367	HELA	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.96	0.42
121544	BRD-K23984367	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129420	BRD-K23984367	A375	0.25 uM	24 h	0.0	0.0	0.0	0.28	0.97	0.36
129541	BRD-K23984367	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary