CMap Candidate Details
Structure:
| CMap ID: | C05018 |
| Pert ID: | BRD-A89164055 |
| Compound Name: | sorbinil |
| Targets: | AKR1B1 |
| MoA: | aldose reductase inhibitor |
| SMILES: | Fc1ccc2OCCC3(NC(=O)NC3=O)c2c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 127730 | BRD-A89164055 | A375 | 10 uM | 24 h | -0.27 | -1.13 | 0.41 | 0.0 | 0.0 | 0.0 |
| 127772 | BRD-A89164055 | A549 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127812 | BRD-A89164055 | HA1E | 3.33 uM | 24 h | 0.22 | 0.9 | 0.02 | 0.0 | 0.0 | 0.0 |
| 127850 | BRD-A89164055 | HEK293 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.96 | 0.42 |
| 127924 | BRD-A89164055 | HUVEC | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.14 | 1.03 |
| 127978 | BRD-A89164055 | MCF10A | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128021 | BRD-A89164055 | MCF??7.00 | 0.04 uM | 24 h | -0.2 | -0.85 | 0.01 | 0.0 | 0.0 | 0.0 |
| 128069 | BRD-A89164055 | YAPC | 0.04 uM | 24 h | 0.24 | 0.99 | 0.09 | 0.26 | 0.92 | 0.25 |
| 135551 | BRD-A89164055 | HELA | 0.08 uM | 24 h | 0.21 | 0.87 | 0.01 | -0.21 | -0.72 | 0.04 |
| 135600 | BRD-A89164055 | HT29 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135642 | BRD-A89164055 | JURKAT | 0.03 uM | 24 h | -0.26 | -1.09 | 0.31 | 0.27 | 0.96 | 0.34 |
| 135713 | BRD-A89164055 | PC3 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |