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CMap Candidate Details

Structure:
CMap ID: C05023
Pert ID: BRD-K16761703
Compound Name: sotrastaurin
Targets: PRKCA|PRKCB|PRKCD|PRKCE|PRKCH|PRKCQ
MoA: PKC inhibitor
SMILES: CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
46 BRD-K16761703 BJAB 0.01 uM 4 h 0.0 0.0 0.0 -0.38 -1.27 1.44
82 BRD-K16761703 HBL1 2.5 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
147 BRD-K16761703 K562 10 uM 4 h 0.0 0.0 0.0 0.31 1.1 0.7
168 BRD-K16761703 KMS34 10 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
210 BRD-K16761703 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
249 BRD-K16761703 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
282 BRD-K16761703 OCILY19 2.5 uM 24 h 0.26 1.09 0.23 0.37 1.32 1.6
326 BRD-K16761703 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
366 BRD-K16761703 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
401 BRD-K16761703 THP1 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
437 BRD-K16761703 TMD8 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95790 BRD-K16761703 MCF??7.00 10 uM 6 h 0.3 1.26 0.56 0.41 1.44 2.21
95805 BRD-K16761703 NPC 10 uM 6 h -0.22 -0.91 0.05 0.0 0.0 0.0
120277 BRD-K16761703 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120315 BRD-K16761703 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120376 BRD-K16761703 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120435 BRD-K16761703 PC3 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
120473 BRD-K16761703 YAPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
128889 BRD-K16761703 A375 2.22 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.57
128926 BRD-K16761703 HELA 2.22 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).