CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05062
Pert ID:	BRD-K50495309
Compound Name:	SRC-kinase-inhibitor-I
Targets:	CSK\|LCK\|RIPK2
MoA:	src inhibitor
SMILES:	COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6769	BRD-K50495309	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7170	BRD-K50495309	A549	10 uM	6 h	-0.22	-0.93	0.07	-0.37	-1.24	1.3
7336	BRD-K50495309	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7676	BRD-K50495309	HCC515	10 uM	6 h	-0.2	-0.82	0.0	0.0	0.0	0.0
7882	BRD-K50495309	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
8102	BRD-K50495309	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
8382	BRD-K50495309	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
8694	BRD-K50495309	VCAP	10 uM	24 h	-0.23	-0.95	0.09	-0.27	-0.9	0.29
87281	BRD-K50495309	BJAB	10 uM	24 h	0.23	0.97	0.08	0.0	0.0	0.0
87333	BRD-K50495309	HBL1	2.5 uM	24 h	0.25	1.04	0.14	0.32	1.13	0.84
87381	BRD-K50495309	K562	10 uM	24 h	-0.22	-0.91	0.06	0.38	1.34	1.72
87430	BRD-K50495309	KMS34	10 uM	24 h	-0.18	-0.73	0.0	0.0	0.0	0.0
87511	BRD-K50495309	MINO	10 uM	6 h	-0.28	-1.15	0.43	0.0	0.0	0.0
87532	BRD-K50495309	NALM6	0.125 uM	24 h	-0.24	-1.01	0.16	-0.26	-0.86	0.21
87582	BRD-K50495309	OCILY10	10 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.49
87634	BRD-K50495309	OCILY19	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87683	BRD-K50495309	OCILY3	10 uM	24 h	0.0	0.0	0.0	0.34	1.21	1.13
87734	BRD-K50495309	SKMEL5	10 uM	24 h	0.0	0.0	0.0	0.4	1.42	2.2
87810	BRD-K50495309	THP1	10 uM	6 h	0.0	0.0	0.0	-0.37	-1.23	1.28
87825	BRD-K50495309	TMD8	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.13

Summary