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CMap Candidate Details

Structure:
CMap ID: C05074
Pert ID: BRD-K40853697
Compound Name: STAT3-inhibitor-VI
Targets: STAT3
MoA: STAT inhibitor
SMILES: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9201 BRD-K40853697 A549 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9421 BRD-K40853697 AGS 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10513 BRD-K40853697 HCT116 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11484 BRD-K40853697 NCIH2073 150 uM 6 h -0.27 -1.14 0.42 -0.23 -0.78 0.09
11762 BRD-K40853697 NCIH508 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12313 BRD-K40853697 NOMO1 150 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.77
12788 BRD-K40853697 SW480 150 uM 6 h 0.24 1.01 0.12 0.0 0.0 0.0
12959 BRD-K40853697 THP1 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13619 BRD-K40853697 VCAP 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96858 BRD-K40853697 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116376 BRD-K40853697 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116423 BRD-K40853697 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116475 BRD-K40853697 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.97
116525 BRD-K40853697 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116572 BRD-K40853697 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
116611 BRD-K40853697 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).