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CMap Candidate Details

Structure:
CMap ID: C05089
Pert ID: BRD-A09094913
Compound Name: strychnine
Targets: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA10|CHRNA9|GLRA1|GLRA2|GLRA3|GLRB
MoA: acetylcholine receptor antagonist
SMILES: O=C1CC2OCC=C3CN4CC[C@@]56C4C[C@@H]3[C@@H]2C5N1c1ccccc61
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5250 BRD-A09094913 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
5711 BRD-A09094913 HCC515 10 uM 6 h 0.0 0.0 0.0 0.42 1.48 2.25
5821 BRD-A09094913 HEPG2 10 uM 6 h 0.25 1.02 0.13 0.0 0.0 0.0
6121 BRD-A09094913 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6449 BRD-A09094913 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37041 BRD-A09094913 A375 10 uM 6 h 0.25 1.04 0.15 0.23 0.81 0.09
37324 BRD-A09094913 A549 10 uM 6 h 0.0 0.0 0.0 0.3 1.08 0.65
37439 BRD-A09094913 ASC 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
37978 BRD-A09094913 HT29 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.58
38128 BRD-A09094913 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38293 BRD-A09094913 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38601 BRD-A09094913 PHH 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
38817 BRD-A09094913 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).