CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05176
Pert ID:	BRD-K73237276
Compound Name:	tacalcitol
Targets:	VDR
MoA:	vitamin D receptor agonist
SMILES:	CC(C)[C@H](O)CC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\C2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95308	BRD-K73237276	A549	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.82
95466	BRD-K73237276	U2OS	0.12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
126446	BRD-K73237276	HEK293	0.04 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
126497	BRD-K73237276	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126524	BRD-K73237276	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.29	1.01	0.45
126581	BRD-K73237276	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126608	BRD-K73237276	YAPC	0.37 uM	24 h	0.0	0.0	0.0	-0.26	-0.86	0.22
134354	BRD-K73237276	A375	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134405	BRD-K73237276	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134434	BRD-K73237276	HELA	0.08 uM	24 h	0.25	1.06	0.19	0.0	0.0	0.0
134513	BRD-K73237276	HUVEC	0.03 uM	24 h	0.0	0.0	0.0	-0.41	-1.39	2.02
134571	BRD-K73237276	MCF??7.00	0.74 uM	24 h	-0.28	-1.18	0.51	-0.3	-1.01	0.58
134605	BRD-K73237276	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	-0.37	-1.26	1.36

Summary