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CMap Candidate Details

Structure:
CMap ID: C05180
Pert ID: BRD-K93645900
Compound Name: tadalafil
Targets: PDE11A|PDE5A
MoA: phosphodiesterase inhibitor
SMILES: CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5809 BRD-K93645900 HCC515 10 uM 6 h 0.31 1.28 0.61 0.0 0.0 0.0
5964 BRD-K93645900 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24703 BRD-K93645900 A549 10 uM 6 h 0.2 0.85 0.0 0.0 0.0 0.0
25449 BRD-K93645900 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37763 BRD-K93645900 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38229 BRD-K93645900 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.16 -0.52 0.0
96735 BRD-K93645900 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96787 BRD-K93645900 PC3 1.11 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
128428 BRD-K93645900 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
128473 BRD-K93645900 HELA 0.04 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
128499 BRD-K93645900 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128538 BRD-K93645900 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
128631 BRD-K93645900 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128711 BRD-K93645900 THP1 3.33 uM 24 h 0.22 0.93 0.04 -0.37 -1.24 1.35
136217 BRD-K93645900 HA1E 0.25 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
136307 BRD-K93645900 MCF10A 0.74 uM 24 h -0.27 -1.14 0.42 0.26 0.94 0.28
136383 BRD-K93645900 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).