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CMap Candidate Details

Structure:
CMap ID: C05189
Pert ID: BRD-K52751261
Compound Name: TAK-715
Targets: MAPK14
MoA: p38 MAPK inhibitor
SMILES: CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
42 BRD-K52751261 BJAB 0.66 uM 4 h -0.2 -0.85 0.01 0.0 0.0 0.0
80 BRD-K52751261 HBL1 10 uM 24 h -0.19 -0.81 0.0 -0.41 -1.37 2.02
144 BRD-K52751261 K562 10 uM 4 h -0.25 -1.04 0.21 0.0 0.0 0.0
163 BRD-K52751261 KMS34 10 uM 24 h 0.28 1.15 0.32 -0.3 -0.99 0.51
206 BRD-K52751261 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
244 BRD-K52751261 OCILY10 10 uM 24 h 0.3 1.26 0.56 -0.29 -0.98 0.47
304 BRD-K52751261 OCILY19 10 uM 4 h 0.19 0.8 0.0 -0.29 -0.98 0.47
322 BRD-K52751261 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
362 BRD-K52751261 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
456 BRD-K52751261 TMD8 10 uM 4 h 0.0 0.0 0.0 -0.32 -1.07 0.77
34906 BRD-K52751261 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
36284 BRD-K52751261 PHH 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
36584 BRD-K52751261 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36976 BRD-K52751261 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91547 BRD-K52751261 BT20 10 uM 6 h 0.25 1.04 0.14 0.0 0.0 0.0
91579 BRD-K52751261 HS578T 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91634 BRD-K52751261 MCF10A 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91657 BRD-K52751261 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
91749 BRD-K52751261 SKBR3 10 uM 24 h 0.16 0.67 0.0 -0.28 -0.95 0.4
94472 BRD-K52751261 ASC 10 uM 24 h 0.25 1.03 0.13 -0.32 -1.06 0.75
94535 BRD-K52751261 CD34 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94588 BRD-K52751261 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94729 BRD-K52751261 HME1 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
94824 BRD-K52751261 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95002 BRD-K52751261 NEU 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95069 BRD-K52751261 NPC 10 uM 24 h -0.25 -1.04 0.21 0.24 0.84 0.13
95148 BRD-K52751261 SHSY5Y 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
95230 BRD-K52751261 SKL 1.11 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
95261 BRD-K52751261 THP1 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
95311 BRD-K52751261 A549 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95422 BRD-K52751261 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.39 -1.31 1.71
124272 BRD-K52751261 A375 10 uM 24 h 0.35 1.47 1.12 0.0 0.0 0.0
124297 BRD-K52751261 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124346 BRD-K52751261 HELA 10 uM 24 h 0.26 1.09 0.22 -0.44 -1.5 15.35
124409 BRD-K52751261 JURKAT 0.37 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
124512 BRD-K52751261 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124540 BRD-K52751261 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132417 BRD-K52751261 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
132458 BRD-K52751261 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.61
132547 BRD-K52751261 MDAMB231 0.01 uM 24 h 0.28 1.17 0.36 0.3 1.06 0.59
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).