CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00052
Pert ID:	BRD-K44276885
Compound Name:	acarbose
Targets:	AMY2A\|GAA\|MGAM\|SI
MoA:	glucosidase inhibitor
SMILES:	C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
44589	BRD-K44276885	A549	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.39
44966	BRD-K44276885	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45261	BRD-K44276885	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
46081	BRD-K44276885	NPC	10 uM	24 h	-0.29	-1.21	0.58	-0.29	-0.97	0.45
46398	BRD-K44276885	PHH	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5
46719	BRD-K44276885	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
49841	BRD-K44276885	A375	10 uM	6 h	-0.29	-1.23	0.63	-0.26	-0.88	0.26
50186	BRD-K44276885	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50534	BRD-K44276885	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50668	BRD-K44276885	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
50840	BRD-K44276885	PC3	10 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19
51149	BRD-K44276885	VCAP	10 uM	6 h	0.24	1.0	0.11	-0.32	-1.08	0.78

Summary