CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05211
Pert ID:	BRD-K74339692
Compound Name:	tamsulosin
Targets:	ADRA1A\|ADRA1B\|ADRA1D
MoA:	adrenergic receptor antagonist
SMILES:	CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91490	BRD-K74339692	HUH7	8 uM	72 h	0.22	0.93	0.05	0.0	0.0	0.0
127039	BRD-K74339692	HA1E	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127160	BRD-K74339692	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127203	BRD-K74339692	MCF??7.00	0.37 uM	24 h	-0.23	-0.94	0.08	0.0	0.0	0.0
127230	BRD-K74339692	PC3	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127273	BRD-K74339692	THP1	3.33 uM	24 h	0.25	1.06	0.19	-0.3	-1.0	0.54
127306	BRD-K74339692	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135013	BRD-K74339692	A375	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135033	BRD-K74339692	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135099	BRD-K74339692	HEK293	0.08 uM	24 h	-0.24	-1.01	0.16	0.0	0.0	0.0
135126	BRD-K74339692	HELA	0.25 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
135144	BRD-K74339692	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135198	BRD-K74339692	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135252	BRD-K74339692	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary