CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05214
Pert ID:	BRD-K89162000
Compound Name:	tandutinib
Targets:	CSF1R\|FLT3\|KIT\|PDGFD\|PDGFRB
MoA:	FLT3 inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor
SMILES:	COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1148	BRD-K89162000	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
1303	BRD-K89162000	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
1380	BRD-K89162000	U2OS	10 uM	6 h	0.27	1.11	0.25	0.31	1.08	0.66
30579	BRD-K89162000	ASC	10 uM	24 h	0.0	0.0	0.0	0.27	0.96	0.34
32250	BRD-K89162000	NEU	10 uM	24 h	0.0	0.0	0.0	0.34	1.22	1.15
32551	BRD-K89162000	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
33163	BRD-K89162000	SKB	10 uM	24 h	0.27	1.12	0.26	0.32	1.14	0.87
33516	BRD-K89162000	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
117655	BRD-K89162000	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117799	BRD-K89162000	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117849	BRD-K89162000	HEPG2	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127814	BRD-K89162000	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127853	BRD-K89162000	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127927	BRD-K89162000	HUVEC	10 uM	24 h	0.25	1.03	0.14	0.32	1.12	0.77
127981	BRD-K89162000	MCF10A	0.125 uM	24 h	-0.16	-0.67	0.0	0.29	1.02	0.47
128071	BRD-K89162000	YAPC	10 uM	24 h	0.0	0.0	0.0	0.38	1.35	1.72
135554	BRD-K89162000	HELA	0.08 uM	24 h	-0.31	-1.29	0.77	0.4	1.43	2.21
135602	BRD-K89162000	HT29	0.03 uM	24 h	-0.23	-0.96	0.1	-0.25	-0.85	0.19
135645	BRD-K89162000	JURKAT	0.25 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.92
135715	BRD-K89162000	PC3	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary