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CMap Candidate Details

Structure:
CMap ID: C05215
Pert ID: BRD-K81473043
Compound Name: tanespimycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9239 BRD-K81473043 A549 0.37 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.51
9519 BRD-K81473043 AGS 0.37 uM 6 h 0.16 0.68 0.0 0.0 0.0 0.0
9824 BRD-K81473043 H1299 0.37 uM 6 h 0.0 0.0 0.0 0.25 0.89 0.2
10857 BRD-K81473043 HEPG2 0.37 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.17
11585 BRD-K81473043 NCIH2073 0.37 uM 6 h -0.31 -1.28 0.74 -0.26 -0.86 0.22
11848 BRD-K81473043 NCIH508 0.37 uM 6 h 0.0 0.0 0.0 0.35 1.24 1.27
12144 BRD-K81473043 NCIH596 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12389 BRD-K81473043 NOMO1 0.37 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.09
12877 BRD-K81473043 SW480 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13034 BRD-K81473043 THP1 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13369 BRD-K81473043 U937 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13504 BRD-K81473043 VCAP 0.37 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
82716 BRD-K81473043 A375 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
82997 BRD-K81473043 HCC515 4 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
83185 BRD-K81473043 HT29 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
83358 BRD-K81473043 PC3 4 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
90627 BRD-K81473043 HCT116 0.37 uM 24 h 0.26 1.1 0.24 0.21 0.76 0.05
90687 BRD-K81473043 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95982 BRD-K81473043 PHH 10 uM 24 h 0.29 1.22 0.48 0.35 1.23 1.19
97986 BRD-K81473043 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
98062 BRD-K81473043 P1A82 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99095 BRD-K81473043 NEU 10 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
99254 BRD-K81473043 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
106360 BRD-K81473043 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116904 BRD-K81473043 MCF??7.00 10 uM 24 h -0.19 -0.8 0.0 -0.34 -1.13 1.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).