CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05223
Pert ID:	BRD-K35169477
Compound Name:	taranabant
Targets:	CNR1
MoA:	cannabinoid receptor inverse agonist
SMILES:	C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc1ccc(Cl)cc1)c1cccc(c1)C#N
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96493	BRD-K35169477	A375	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.16	1.11
96561	BRD-K35169477	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121930	BRD-K35169477	A549	0.04 uM	24 h	-0.28	-1.18	0.5	-0.25	-0.85	0.2
121947	BRD-K35169477	HA1E	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121996	BRD-K35169477	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122029	BRD-K35169477	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122084	BRD-K35169477	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18
122129	BRD-K35169477	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122208	BRD-K35169477	THP1	0.04 uM	24 h	-0.27	-1.13	0.41	0.23	0.83	0.11
122230	BRD-K35169477	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130275	BRD-K35169477	HEK293	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130384	BRD-K35169477	JURKAT	0.74 uM	24 h	0.22	0.93	0.04	0.31	1.11	0.72
130424	BRD-K35169477	MCF10A	0.01 uM	24 h	-0.26	-1.09	0.33	0.28	0.98	0.38
130470	BRD-K35169477	MDAMB231	0.01 uM	24 h	-0.23	-0.96	0.09	0.0	0.0	0.0

Summary