CMap Candidate Details
Structure:
| CMap ID: | C05227 |
| Pert ID: | BRD-K09426783 |
| Compound Name: | TAS-103 |
| Targets: | TOP1 |
| MoA: | topoisomerase inhibitor |
| SMILES: | CN(C)CCNc1nc2cc(O)ccc2c2-c3ccccc3C(=O)c12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 121187 | BRD-K09426783 | A549 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121316 | BRD-K09426783 | PC3 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.44 | -1.48 | 15.35 |
| 129244 | BRD-K09426783 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129253 | BRD-K09426783 | HA1E | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.21 | -0.71 | 0.03 |
| 129262 | BRD-K09426783 | HELA | 0.03 uM | 24 h | 0.25 | 1.04 | 0.14 | 0.0 | 0.0 | 0.0 |
| 129298 | BRD-K09426783 | HT29 | 2.22 uM | 24 h | 0.33 | 1.38 | 0.97 | 0.0 | 0.0 | 0.0 |
| 129333 | BRD-K09426783 | MCF??7.00 | 0.25 uM | 24 h | -0.22 | -0.93 | 0.07 | -0.4 | -1.34 | 1.85 |
| 129373 | BRD-K09426783 | YAPC | 0.08 uM | 24 h | 0.27 | 1.11 | 0.26 | 0.0 | 0.0 | 0.0 |