CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05238
Pert ID:	BRD-K76841105
Compound Name:	tazarotene
Targets:	RARA\|RARB\|RARG\|RXRB
MoA:	retinoid receptor agonist
SMILES:	CCOC(=O)c1ccc(nc1)C#Cc1ccc2SCCC(C)(C)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96632	BRD-K76841105	A375	3.33 uM	24 h	-0.21	-0.89	0.03	0.0	0.0	0.0
127046	BRD-K76841105	HA1E	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127104	BRD-K76841105	HELA	1.11 uM	24 h	-0.19	-0.8	0.0	0.0	0.0	0.0
127186	BRD-K76841105	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127244	BRD-K76841105	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127319	BRD-K76841105	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135047	BRD-K76841105	A549	2.22 uM	24 h	0.27	1.12	0.26	0.0	0.0	0.0
135110	BRD-K76841105	HEK293	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135149	BRD-K76841105	HT29	0.08 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.69
135176	BRD-K76841105	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18
135231	BRD-K76841105	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.51
135271	BRD-K76841105	MDAMB231	0.74 uM	24 h	0.23	0.95	0.06	0.0	0.0	0.0
135310	BRD-K76841105	THP1	0.74 uM	24 h	-0.26	-1.07	0.28	-0.28	-0.93	0.35

Summary