CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05349
Pert ID:	BRD-K95739795
Compound Name:	tetrabenazine
Targets:	DRD2\|SLC18A1\|SLC18A2
MoA:	vesicular monoamine transporter inhibitor
SMILES:	COc1cc2CCN3C[C@H](CC(C)C)C(=O)C[C@H]3c2cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6817	BRD-K95739795	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7733	BRD-K95739795	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.26	-0.87	0.22
8738	BRD-K95739795	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
98165	BRD-K95739795	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
98448	BRD-K95739795	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128390	BRD-K95739795	A549	0.04 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.53
128445	BRD-K95739795	HEK293	1.11 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0
128481	BRD-K95739795	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128555	BRD-K95739795	JURKAT	0.04 uM	24 h	-0.25	-1.06	0.25	0.0	0.0	0.0
128597	BRD-K95739795	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	-0.28	-0.96	0.43
128647	BRD-K95739795	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128684	BRD-K95739795	PC3	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128727	BRD-K95739795	THP1	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128772	BRD-K95739795	YAPC	0.37 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.78
136231	BRD-K95739795	HA1E	0.74 uM	24 h	-0.18	-0.75	0.0	0.0	0.0	0.0
136294	BRD-K95739795	HT29	0.08 uM	24 h	0.26	1.07	0.19	0.0	0.0	0.0
136348	BRD-K95739795	MCF??7.00	0.03 uM	24 h	0.25	1.04	0.14	-0.24	-0.81	0.14

Summary