CMap Candidate Details
Structure:
| CMap ID: | C00535 |
| Pert ID: | BRD-K99023089 |
| Compound Name: | AZD5363 |
| Targets: | AKT1|AKT2|AKT3 |
| MoA: | AKT inhibitor |
| SMILES: | NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1227 | BRD-K99023089 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.18 | 1.14 |
| 1305 | BRD-K99023089 | MCF??7.00 | 10 uM | 6 h | 0.24 | 0.99 | 0.1 | 0.0 | 0.0 | 0.0 |
| 1393 | BRD-K99023089 | U2OS | 10 uM | 6 h | -0.23 | -0.97 | 0.11 | 0.0 | 0.0 | 0.0 |
| 127754 | BRD-K99023089 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127832 | BRD-K99023089 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127882 | BRD-K99023089 | HEK293 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.25 | -0.85 | 0.2 |
| 127905 | BRD-K99023089 | HT29 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.46 | -1.53 | 15.35 |
| 127956 | BRD-K99023089 | HUVEC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128007 | BRD-K99023089 | MCF10A | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.31 | 1.7 |
| 128056 | BRD-K99023089 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128089 | BRD-K99023089 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.06 | 0.73 |
| 135583 | BRD-K99023089 | HELA | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.93 | 0.34 |
| 135674 | BRD-K99023089 | JURKAT | 2.22 uM | 24 h | -0.21 | -0.89 | 0.03 | -0.34 | -1.14 | 1.02 |