CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05350
Pert ID:	BRD-K45071273
Compound Name:	tetracaine
Targets:	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A
MoA:	membrane integrity inhibitor
SMILES:	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
114791	BRD-K45071273	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
125584	BRD-K45071273	A375	1.11 uM	24 h	0.2	0.84	0.0	0.24	0.86	0.16
125696	BRD-K45071273	HT29	10 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.24
125736	BRD-K45071273	HUVEC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125852	BRD-K45071273	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
125934	BRD-K45071273	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133669	BRD-K45071273	A549	0.74 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
133700	BRD-K45071273	HA1E	0.01 uM	24 h	-0.23	-0.94	0.08	0.0	0.0	0.0
133732	BRD-K45071273	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133768	BRD-K45071273	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133826	BRD-K45071273	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133858	BRD-K45071273	MCF10A	0.74 uM	24 h	-0.28	-1.19	0.51	0.0	0.0	0.0
133884	BRD-K45071273	MCF??7.00	0.03 uM	24 h	0.28	1.18	0.39	-0.27	-0.91	0.3
133944	BRD-K45071273	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.22	0.77	0.05
133980	BRD-K45071273	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary