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CMap Candidate Details

Structure:
CMap ID: C00536
Pert ID: BRD-K72414522
Compound Name: AZD5438
Targets: KCNH2
MoA: CDK inhibitor
SMILES: CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
516 BRD-K72414522 BJAB 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
564 BRD-K72414522 HBL1 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
609 BRD-K72414522 K562 2.5 uM 4 h 0.0 0.0 0.0 0.34 1.2 1.07
654 BRD-K72414522 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
700 BRD-K72414522 MINO 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
748 BRD-K72414522 NALM6 0.66 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.18
776 BRD-K72414522 OCILY19 0.125 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
842 BRD-K72414522 OCILY3 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
890 BRD-K72414522 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
931 BRD-K72414522 THP1 0.66 uM 24 h 0.25 1.02 0.13 0.0 0.0 0.0
947 BRD-K72414522 TMD8 0.125 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.05
91850 BRD-K72414522 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
91882 BRD-K72414522 MCF??7.00 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91901 BRD-K72414522 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92412 BRD-K72414522 A375 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92471 BRD-K72414522 BT20 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92539 BRD-K72414522 HME1 0.37 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
92584 BRD-K72414522 HS578T 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92674 BRD-K72414522 LNCAP 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92831 BRD-K72414522 SKBR3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95386 BRD-K72414522 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126408 BRD-K72414522 HA1E 0.37 uM 24 h 0.2 0.82 0.0 -0.3 -1.01 0.57
126452 BRD-K72414522 HEK293 1.11 uM 24 h -0.27 -1.14 0.43 0.0 0.0 0.0
126482 BRD-K72414522 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
134382 BRD-K72414522 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134472 BRD-K72414522 HT29 0.74 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
134519 BRD-K72414522 HUVEC 0.74 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
134632 BRD-K72414522 PC3 0.08 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.52
134657 BRD-K72414522 YAPC 0.74 uM 24 h 0.21 0.89 0.02 0.29 1.02 0.49
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).