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CMap Candidate Details

Structure:
CMap ID: C05364
Pert ID: BRD-K97101532
Compound Name: tezacaftor
Targets:
MoA: CFTR channel agonist
SMILES: CC(C)(CO)c1cc2cc(NC(=O)C3(CC3)c3ccc4OC(F)(F)Oc4c3)c(F)cc2n1C[C@@H](O)CO
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128110 BRD-K97101532 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128140 BRD-K97101532 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
128168 BRD-K97101532 HEK293 10 uM 24 h -0.22 -0.93 0.07 -0.35 -1.19 1.15
128222 BRD-K97101532 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128260 BRD-K97101532 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128301 BRD-K97101532 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128332 BRD-K97101532 PC3 3.33 uM 24 h -0.19 -0.78 0.0 0.32 1.15 0.88
128354 BRD-K97101532 THP1 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
135811 BRD-K97101532 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
135896 BRD-K97101532 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135941 BRD-K97101532 HT29 2.22 uM 24 h -0.23 -0.94 0.08 -0.32 -1.08 0.79
135985 BRD-K97101532 JURKAT 0.74 uM 24 h 0.19 0.78 0.0 -0.22 -0.75 0.06
136131 BRD-K97101532 YAPC 0.01 uM 24 h 0.22 0.91 0.03 0.24 0.85 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).