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CMap Candidate Details

Structure:
CMap ID: C05372
Pert ID: BRD-K12502280
Compound Name: TG-101348
Targets: BRD4|JAK1|JAK2|JAK3|TYK2
MoA: FLT3 inhibitor; JAK inhibitor
SMILES: Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
475 BRD-K12502280 BJAB 2.5 uM 24 h 0.21 0.89 0.02 -0.28 -0.96 0.43
521 BRD-K12502280 HBL1 2.5 uM 24 h 0.0 0.0 0.0 -0.45 -1.5 15.35
586 BRD-K12502280 K562 0.125 uM 4 h 0.0 0.0 0.0 -0.22 -0.74 0.05
613 BRD-K12502280 KMS34 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
658 BRD-K12502280 MINO 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
705 BRD-K12502280 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
780 BRD-K12502280 OCILY19 0.66 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
821 BRD-K12502280 OCILY3 0.01 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
846 BRD-K12502280 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
895 BRD-K12502280 THP1 2.5 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
932 BRD-K12502280 TMD8 0.66 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
9033 BRD-K12502280 A375 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9085 BRD-K12502280 A549 12 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
9365 BRD-K12502280 AGS 12 uM 6 h 0.0 0.0 0.0 0.39 1.38 2.14
9672 BRD-K12502280 H1299 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10736 BRD-K12502280 HEPG2 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11074 BRD-K12502280 HT29 12 uM 6 h -0.17 -0.71 0.0 0.29 1.01 0.45
11424 BRD-K12502280 NCIH2073 12 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.41
11715 BRD-K12502280 NCIH508 12 uM 6 h 0.0 0.0 0.0 -0.23 -0.79 0.1
11992 BRD-K12502280 NCIH596 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12271 BRD-K12502280 NOMO1 12 uM 6 h 0.19 0.8 0.0 0.21 0.74 0.03
12736 BRD-K12502280 SW480 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13215 BRD-K12502280 U937 12 uM 6 h 0.19 0.79 0.0 0.0 0.0 0.0
90390 BRD-K12502280 VCAP 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
90605 BRD-K12502280 HCT116 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
91864 BRD-K12502280 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91888 BRD-K12502280 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
92044 BRD-K12502280 BT20 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92165 BRD-K12502280 HS578T 3.33 uM 3 h 0.31 1.28 0.6 0.0 0.0 0.0
92239 BRD-K12502280 MCF10A 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92347 BRD-K12502280 PC3 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
92373 BRD-K12502280 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95849 BRD-K12502280 NPC 8 uM 6 h -0.21 -0.85 0.01 0.35 1.24 1.28
95907 BRD-K12502280 YAPC 8 uM 6 h 0.2 0.83 0.0 0.0 0.0 0.0
97254 BRD-K12502280 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98091 BRD-K12502280 P1A82 3.33 uM 24 h 0.0 0.0 0.0 -0.38 -1.26 1.39
117741 BRD-K12502280 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117789 BRD-K12502280 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).