Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05375
Pert ID: BRD-K64785675
Compound Name: TG100-115
Targets: PIK3CA|PIK3CB|PIK3CD|PIK3CG
MoA: PI3K inhibitor
SMILES: Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30513 BRD-K64785675 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
31100 BRD-K64785675 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31409 BRD-K64785675 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32491 BRD-K64785675 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
33096 BRD-K64785675 SKB 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
33334 BRD-K64785675 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97323 BRD-K64785675 HAP1 3.33 uM 24 h 0.22 0.91 0.03 0.25 0.89 0.2
97363 BRD-K64785675 A375 0.66 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
124971 BRD-K64785675 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125098 BRD-K64785675 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125169 BRD-K64785675 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
125212 BRD-K64785675 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133015 BRD-K64785675 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133056 BRD-K64785675 HEK293 0.01 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
133092 BRD-K64785675 HELA 0.74 uM 24 h -0.29 -1.22 0.6 0.0 0.0 0.0
133121 BRD-K64785675 HT29 0.74 uM 24 h 0.25 1.03 0.13 0.27 0.97 0.34
133163 BRD-K64785675 JURKAT 0.25 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
133201 BRD-K64785675 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
133263 BRD-K64785675 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133295 BRD-K64785675 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).