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CMap Candidate Details

Structure:
CMap ID: C05378
Pert ID: BRD-A93255169
Compound Name: thalidomide
Targets: CRBN|FGFR2|NFKB1|ORM1|ORM2|PTGS2|TNF
MoA: tumor necrosis factor production inhibitor
SMILES: O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8889 BRD-A93255169 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9078 BRD-A93255169 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.28
9321 BRD-A93255169 AGS 10 uM 6 h -0.28 -1.19 0.52 0.2 0.69 0.01
9624 BRD-A93255169 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10426 BRD-A93255169 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11376 BRD-A93255169 NCIH2073 10 uM 6 h 0.28 1.15 0.34 0.0 0.0 0.0
11946 BRD-A93255169 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12229 BRD-A93255169 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12973 BRD-A93255169 THP1 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.03
44798 BRD-A93255169 ASC 10 uM 24 h -0.28 -1.17 0.5 0.0 0.0 0.0
45918 BRD-A93255169 NPC 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
46236 BRD-A93255169 PHH 10 uM 24 h -0.28 -1.15 0.44 0.2 0.72 0.03
46549 BRD-A93255169 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50997 BRD-A93255169 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91463 BRD-A93255169 HUH7 12.5 uM 72 h 0.27 1.14 0.32 0.0 0.0 0.0
98984 BRD-A93255169 NEU 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
100398 BRD-A93255169 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
118123 BRD-A93255169 HA1E 0.125 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
118169 BRD-A93255169 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118218 BRD-A93255169 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118345 BRD-A93255169 PC3 1.11 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
128179 BRD-A93255169 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128203 BRD-A93255169 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128253 BRD-A93255169 MCF??7.00 1.11 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
128282 BRD-A93255169 MDAMB231 0.37 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
135838 BRD-A93255169 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135877 BRD-A93255169 HELA 0.01 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
135966 BRD-A93255169 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136112 BRD-A93255169 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).