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CMap Candidate Details

Structure:
CMap ID: C05379
Pert ID: BRD-K34888156
Compound Name: theobromine
Targets: ADORA1|ADORA2A|PDE4B
MoA: phosphodiesterase inhibitor
SMILES: Cn1cnc2n(C)c(=O)[nH]c(=O)c12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121913 BRD-K34888156 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121946 BRD-K34888156 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
122028 BRD-K34888156 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122083 BRD-K34888156 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122128 BRD-K34888156 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
122181 BRD-K34888156 PC3 0.04 uM 24 h -0.22 -0.93 0.07 0.2 0.72 0.02
122207 BRD-K34888156 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130214 BRD-K34888156 A549 2.22 uM 24 h -0.24 -1.02 0.18 0.26 0.92 0.25
130274 BRD-K34888156 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.19
130310 BRD-K34888156 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.19 0.68 0.01
130383 BRD-K34888156 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
130423 BRD-K34888156 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130469 BRD-K34888156 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
130544 BRD-K34888156 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).