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CMap Candidate Details

Structure:
CMap ID: C00538
Pert ID: BRD-K58772419
Compound Name: AZD6482
Targets: PIK3CA|PIK3CB|PIK3CD|PIK3CG
MoA: PI3K inhibitor
SMILES: C[C@@H](Nc1ccccc1C(O)=O)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33604 BRD-K58772419 A375 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.76
34132 BRD-K58772419 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34384 BRD-K58772419 HA1E 10 uM 6 h 0.0 0.0 0.0 0.22 0.77 0.06
35588 BRD-K58772419 NEU 10 uM 24 h -0.25 -1.04 0.22 0.24 0.85 0.15
35805 BRD-K58772419 NPC 10 uM 24 h -0.23 -0.98 0.12 -0.34 -1.14 1.01
36291 BRD-K58772419 PHH 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
36592 BRD-K58772419 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36840 BRD-K58772419 VCAP 10 uM 24 h -0.16 -0.66 0.0 0.24 0.85 0.14
91516 BRD-K58772419 BT20 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
92139 BRD-K58772419 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92233 BRD-K58772419 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 -0.26 -0.87 0.23
92312 BRD-K58772419 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.24 0.85 0.14
92341 BRD-K58772419 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92369 BRD-K58772419 SKBR3 0.12 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
96158 BRD-K58772419 A549 10 uM 24 h -0.33 -1.39 1.13 -0.32 -1.09 0.83
97250 BRD-K58772419 HAP1 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.52
115738 BRD-K58772419 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115779 BRD-K58772419 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115827 BRD-K58772419 HT29 3.33 uM 24 h 0.31 1.29 0.64 -0.26 -0.88 0.25
115873 BRD-K58772419 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).