CMap Candidate Details
Structure:
| CMap ID: | C05391 |
| Pert ID: | BRD-K49350383 |
| Compound Name: | thioguanine |
| Targets: | IMPDH1|IMPDH2 |
| MoA: | purine antagonist |
| SMILES: | Nc1nc2nc[nH]c2c(=S)[nH]1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 125262 | BRD-K49350383 | A549 | 10 uM | 24 h | -0.18 | -0.74 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125284 | BRD-K49350383 | HA1E | 10 uM | 24 h | -0.18 | -0.73 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125324 | BRD-K49350383 | HEK293 | 3.33 uM | 24 h | 0.29 | 1.2 | 0.43 | 0.0 | 0.0 | 0.0 |
| 125356 | BRD-K49350383 | HELA | 0.125 uM | 24 h | 0.21 | 0.9 | 0.02 | -0.28 | -0.94 | 0.36 |
| 125379 | BRD-K49350383 | HT29 | 3.33 uM | 24 h | -0.29 | -1.22 | 0.61 | -0.27 | -0.9 | 0.28 |
| 125405 | BRD-K49350383 | JURKAT | 3.33 uM | 24 h | -0.16 | -0.68 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125419 | BRD-K49350383 | MCF10A | 10 uM | 24 h | 0.25 | 1.02 | 0.13 | -0.35 | -1.17 | 1.12 |
| 125453 | BRD-K49350383 | MCF??7.00 | 3.33 uM | 24 h | 0.27 | 1.12 | 0.26 | -0.4 | -1.34 | 1.85 |
| 125476 | BRD-K49350383 | MDAMB231 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125526 | BRD-K49350383 | THP1 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.18 | 0.65 | 0.0 |
| 133346 | BRD-K49350383 | A375 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.02 | 0.61 |
| 133587 | BRD-K49350383 | PC3 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133639 | BRD-K49350383 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |